Abstract
A new group of serotoninergic 5-HT(1A) or 5-HT(7) receptor ligands was identified. These compounds were designed and synthesized on a benzimidazolone scaffold and they enrich the well-known arylpiperazine class of 5-HT ligands. Diverse pharmacomodulations induced a shift in the affinity and selectivity profile with final identification of new potent hits.
MeSH terms
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Benzimidazoles / chemistry*
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Chemistry, Pharmaceutical / methods*
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Drug Design
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Humans
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Kinetics
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Ligands
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Models, Chemical
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Molecular Structure
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Piperazines / chemistry
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Protein Binding
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Receptor, Serotonin, 5-HT1A / chemistry*
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Receptor, Serotonin, 5-HT1A / metabolism
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Receptors, Serotonin / chemistry*
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Receptors, Serotonin / metabolism
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Structure-Activity Relationship
Substances
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Benzimidazoles
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Ligands
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Piperazines
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Receptors, Serotonin
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serotonin 7 receptor
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Receptor, Serotonin, 5-HT1A
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benzimidazolone